HB–R01 / State map
Fibrotic transition topology
A fictional multi-tissue map tests whether a conserved state boundary predicts response to perturbation.
- Comparator
- Held-out state set
- Decision
- Advance to assay
- Confidence
- Illustrative 82%
Evidence library · Illustrative records only
Proof is a chain,
not a score.
Every conclusion should retain its question, comparator, uncertainty and next falsifying experiment.
- Records
- 03 fictional examples
- Patient data
- None included
Selected records · 2026
Three ways a signal earns trust.
HB–R02 / Perturbation
Escape-path screen
A fictional paired perturbation reveals two competing recovery routes and a sharper next experiment.
- Replicates
- Illustrative n=6
- Decision
- Revise combination
HB–R03 / Translation
Response marker bridge
A fictional marker set connects an experimental state shift with a feasible translational readout.
- Modalities
- 3 linked
- Decision
- External review
What travels with every claim.
Question + comparator
What was tested, what it was tested against, and why that contrast answers the program question.
Uncertainty + failure
Confidence range, missing modality, known confounder and the result that would reverse the decision.
Owner + next gate
The accountable reviewer, versioned decision and concrete experiment required before the claim advances.
Independent read
Make the evidence legible to someone who did not build the model.
- 01Methods review
- 02Biology review
- 03Program decision
Methods before metrics